diff --git a/lims_diagnosis/locale/es.po b/lims_diagnosis/locale/es.po
index 95f1640c..f1d6f235 100644
--- a/lims_diagnosis/locale/es.po
+++ b/lims_diagnosis/locale/es.po
@@ -268,6 +268,10 @@ msgctxt "model:ir.message,text:lbl_line_acceptance"
 msgid "Notebook Line Acceptance"
 msgstr "Aceptación de Línea de cuaderno"
 
+msgctxt "model:ir.message,text:msg_invalid_diagnosis_state"
+msgid "Missing diagnosis states"
+msgstr "Faltan estados de diagnóstico"
+
 msgctxt "model:ir.ui.menu,name:lims_open_samples_comparator_menu"
 msgid "Samples Comparator"
 msgstr "Comparador de muestras"
@@ -288,6 +292,10 @@ msgctxt "model:lims.diagnosis.state,name:"
 msgid "Diagnosis State"
 msgstr "Estado de Diagnóstico"
 
+msgctxt "model:lims.diagnosis.state.image,name:"
+msgid "Diagnosis State Image"
+msgstr "Imagen de Estado de diagnóstico"
+
 msgctxt "model:lims.diagnosis.template,name:"
 msgid "Diagnosis Template"
 msgstr "Plantilla de Diagnóstico"
diff --git a/lims_diagnosis/message.xml b/lims_diagnosis/message.xml
index bf1b8599..4a108aed 100644
--- a/lims_diagnosis/message.xml
+++ b/lims_diagnosis/message.xml
@@ -4,5 +4,8 @@
         <record model="ir.message" id="lbl_line_acceptance">
             <field name="text">Notebook Line Acceptance</field>
         </record>
+        <record model="ir.message" id="msg_invalid_diagnosis_state">
+            <field name="text">Missing diagnosis states</field>
+        </record>
     </data>
 </tryton>
diff --git a/lims_diagnosis/results_report.py b/lims_diagnosis/results_report.py
index af3a9a3d..c2ec3f1a 100644
--- a/lims_diagnosis/results_report.py
+++ b/lims_diagnosis/results_report.py
@@ -8,6 +8,7 @@ from trytond.wizard import Wizard, StateTransition, StateView, StateAction, \
 from trytond.pool import Pool, PoolMeta
 from trytond.pyson import Eval, Not, Bool
 from trytond.transaction import Transaction
+from trytond.exceptions import UserError
 from trytond.i18n import gettext
 
 
@@ -37,8 +38,20 @@ class ResultsReportVersionDetail(metaclass=PoolMeta):
     @classmethod
     @ModelView.button
     def diagnose(cls, details):
+        cls.check_diagnosis_states(details)
         cls.write(details, {'state': 'diagnosed'})
 
+    @classmethod
+    def check_diagnosis_states(cls, details):
+        for detail in details:
+            for sample in detail.samples:
+                if not sample.diagnosis_states:
+                    continue
+                for state in sample.diagnosis_states.values():
+                    if state == '*':
+                        raise UserError(gettext(
+                            'lims_diagnosis.msg_invalid_diagnosis_state'))
+
     @fields.depends('template', '_parent_template.diagnosis_template',
         methods=['on_change_diagnosis_template'])
     def on_change_template(self):