diff --git a/news/6886.feature b/news/6886.feature
new file mode 100644
index 000000000..b4f500b1b
--- /dev/null
+++ b/news/6886.feature
@@ -0,0 +1 @@
+Support including a port number in ``--trusted-host`` for both HTTP and HTTPS.
diff --git a/src/pip/_internal/cli/cmdoptions.py b/src/pip/_internal/cli/cmdoptions.py
index 74efaecf9..1bfecef54 100644
--- a/src/pip/_internal/cli/cmdoptions.py
+++ b/src/pip/_internal/cli/cmdoptions.py
@@ -391,8 +391,8 @@ def trusted_host():
         action="append",
         metavar="HOSTNAME",
         default=[],
-        help="Mark this host as trusted, even though it does not have valid "
-             "or any HTTPS.",
+        help="Mark this host or host:port pair as trusted, even though it "
+             "does not have valid or any HTTPS.",
     )
 
 
diff --git a/src/pip/_internal/download.py b/src/pip/_internal/download.py
index 72d4cfc12..b681ccb06 100644
--- a/src/pip/_internal/download.py
+++ b/src/pip/_internal/download.py
@@ -50,7 +50,7 @@ from pip._internal.utils.misc import (
     format_size,
     get_installed_version,
     hide_url,
-    netloc_has_port,
+    parse_netloc,
     path_to_display,
     path_to_url,
     remove_auth_from_url,
@@ -77,7 +77,7 @@ if MYPY_CHECK_RUNNING:
     from pip._internal.vcs.versioncontrol import AuthInfo, VersionControl
 
     Credentials = Tuple[str, str, str]
-    SecureOrigin = Tuple[str, str, Optional[str]]
+    SecureOrigin = Tuple[str, str, Optional[Union[int, str]]]
 
     if PY2:
         CopytreeKwargs = TypedDict(
@@ -586,7 +586,7 @@ class PipSession(requests.Session):
 
         # Namespace the attribute with "pip_" just in case to prevent
         # possible conflicts with the base class.
-        self.pip_trusted_hosts = []  # type: List[str]
+        self.pip_trusted_origins = []  # type: List[Tuple[str, Optional[int]]]
 
         # Attach our User Agent to the request
         self.headers["User-Agent"] = user_agent()
@@ -670,11 +670,12 @@ class PipSession(requests.Session):
                 msg += ' (from {})'.format(source)
             logger.info(msg)
 
-        if host not in self.pip_trusted_hosts:
-            self.pip_trusted_hosts.append(host)
+        host_port = parse_netloc(host)
+        if host_port not in self.pip_trusted_origins:
+            self.pip_trusted_origins.append(host_port)
 
         self.mount(build_url_from_netloc(host) + '/', self._insecure_adapter)
-        if not netloc_has_port(host):
+        if not host_port[1]:
             # Mount wildcard ports for the same host.
             self.mount(
                 build_url_from_netloc(host) + ':',
@@ -685,8 +686,8 @@ class PipSession(requests.Session):
         # type: () -> Iterator[SecureOrigin]
         for secure_origin in SECURE_ORIGINS:
             yield secure_origin
-        for host in self.pip_trusted_hosts:
-            yield ('*', host, '*')
+        for host, port in self.pip_trusted_origins:
+            yield ('*', host, '*' if port is None else port)
 
     def is_secure_origin(self, location):
         # type: (Link) -> bool
diff --git a/src/pip/_internal/index.py b/src/pip/_internal/index.py
index 71331861e..93c198433 100644
--- a/src/pip/_internal/index.py
+++ b/src/pip/_internal/index.py
@@ -38,6 +38,7 @@ from pip._internal.utils.misc import (
     ARCHIVE_EXTENSIONS,
     SUPPORTED_EXTENSIONS,
     WHEEL_EXTENSION,
+    build_netloc,
     path_to_url,
     redact_password_from_url,
 )
@@ -947,7 +948,8 @@ class PackageFinder(object):
     @property
     def trusted_hosts(self):
         # type: () -> Iterable[str]
-        return iter(self.session.pip_trusted_hosts)
+        for host_port in self.session.pip_trusted_origins:
+            yield build_netloc(*host_port)
 
     @property
     def allow_all_prereleases(self):
diff --git a/src/pip/_internal/utils/misc.py b/src/pip/_internal/utils/misc.py
index f6da2a5ab..d19df9459 100644
--- a/src/pip/_internal/utils/misc.py
+++ b/src/pip/_internal/utils/misc.py
@@ -1129,6 +1129,19 @@ def path_to_url(path):
     return url
 
 
+def build_netloc(host, port):
+    # type: (str, Optional[int]) -> str
+    """
+    Build a netloc from a host-port pair
+    """
+    if port is None:
+        return host
+    if ':' in host:
+        # Only wrap host with square brackets when it is IPv6
+        host = '[{}]'.format(host)
+    return '{}:{}'.format(host, port)
+
+
 def build_url_from_netloc(netloc, scheme='https'):
     # type: (str, str) -> str
     """
@@ -1140,14 +1153,14 @@ def build_url_from_netloc(netloc, scheme='https'):
     return '{}://{}'.format(scheme, netloc)
 
 
-def netloc_has_port(netloc):
-    # type: (str) -> bool
+def parse_netloc(netloc):
+    # type: (str) -> Tuple[str, Optional[int]]
     """
-    Return whether the netloc has a port part.
+    Return the host-port pair from a netloc.
     """
     url = build_url_from_netloc(netloc)
     parsed = urllib_parse.urlparse(url)
-    return bool(parsed.port)
+    return parsed.hostname, parsed.port
 
 
 def split_auth_from_netloc(netloc):
diff --git a/tests/unit/test_download.py b/tests/unit/test_download.py
index 42265f327..9c0ccc2cf 100644
--- a/tests/unit/test_download.py
+++ b/tests/unit/test_download.py
@@ -634,24 +634,39 @@ class TestPipSession:
         insecure_adapter = session._insecure_adapter
         prefix2 = 'https://host2/'
         prefix3 = 'https://host3/'
+        prefix3_wildcard = 'https://host3:'
 
         # Confirm some initial conditions as a baseline.
-        assert session.pip_trusted_hosts == ['host1', 'host3']
+        assert session.pip_trusted_origins == [
+            ('host1', None), ('host3', None)
+        ]
         assert session.adapters[prefix3] is insecure_adapter
+        assert session.adapters[prefix3_wildcard] is insecure_adapter
+
         assert prefix2 not in session.adapters
 
         # Test adding a new host.
         session.add_trusted_host('host2')
-        assert session.pip_trusted_hosts == ['host1', 'host3', 'host2']
+        assert session.pip_trusted_origins == [
+            ('host1', None), ('host3', None), ('host2', None)
+        ]
         # Check that prefix3 is still present.
         assert session.adapters[prefix3] is insecure_adapter
         assert session.adapters[prefix2] is insecure_adapter
 
         # Test that adding the same host doesn't create a duplicate.
         session.add_trusted_host('host3')
-        assert session.pip_trusted_hosts == ['host1', 'host3', 'host2'], (
-            'actual: {}'.format(session.pip_trusted_hosts)
-        )
+        assert session.pip_trusted_origins == [
+            ('host1', None), ('host3', None), ('host2', None)
+        ], 'actual: {}'.format(session.pip_trusted_origins)
+
+        session.add_trusted_host('host4:8080')
+        prefix4 = 'https://host4:8080/'
+        assert session.pip_trusted_origins == [
+            ('host1', None), ('host3', None),
+            ('host2', None), ('host4', 8080)
+        ]
+        assert session.adapters[prefix4] is insecure_adapter
 
     def test_add_trusted_host__logging(self, caplog):
         """
@@ -676,16 +691,17 @@ class TestPipSession:
         assert actual == expected
 
     def test_iter_secure_origins(self):
-        trusted_hosts = ['host1', 'host2']
+        trusted_hosts = ['host1', 'host2', 'host3:8080']
         session = PipSession(trusted_hosts=trusted_hosts)
 
         actual = list(session.iter_secure_origins())
-        assert len(actual) == 8
+        assert len(actual) == 9
         # Spot-check that SECURE_ORIGINS is included.
         assert actual[0] == ('https', '*', '*')
-        assert actual[-2:] == [
+        assert actual[-3:] == [
             ('*', 'host1', '*'),
             ('*', 'host2', '*'),
+            ('*', 'host3', 8080)
         ]
 
     def test_iter_secure_origins__trusted_hosts_empty(self):
@@ -713,6 +729,16 @@ class TestPipSession:
             ("http://example.com/something/", ["example.com"], True),
             # Try changing the case.
             ("http://eXample.com/something/", ["example.cOm"], True),
+            # Test hosts with port.
+            ("http://example.com:8080/something/", ["example.com"], True),
+            # Test a trusted_host with a port.
+            ("http://example.com:8080/something/", ["example.com:8080"], True),
+            ("http://example.com/something/", ["example.com:8080"], False),
+            (
+                "http://example.com:8888/something/",
+                ["example.com:8080"],
+                False
+            ),
         ],
     )
     def test_is_secure_origin(self, caplog, location, trusted, expected):
diff --git a/tests/unit/test_req_file.py b/tests/unit/test_req_file.py
index a11532707..443a76054 100644
--- a/tests/unit/test_req_file.py
+++ b/tests/unit/test_req_file.py
@@ -345,19 +345,23 @@ class TestProcessLine(object):
     def test_set_finder_trusted_host(self, caplog, session, finder):
         with caplog.at_level(logging.INFO):
             list(process_line(
-                "--trusted-host=host", "file.txt", 1, finder=finder,
-                session=session,
+                "--trusted-host=host1 --trusted-host=host2:8080",
+                "file.txt", 1, finder=finder, session=session,
             ))
-        assert list(finder.trusted_hosts) == ['host']
+        assert list(finder.trusted_hosts) == ['host1', 'host2:8080']
         session = finder.session
-        assert session.adapters['https://host/'] is session._insecure_adapter
+        assert session.adapters['https://host1/'] is session._insecure_adapter
+        assert (
+            session.adapters['https://host2:8080/']
+            is session._insecure_adapter
+        )
 
         # Test the log message.
         actual = [(r.levelname, r.message) for r in caplog.records]
-        expected = [
-            ('INFO', "adding trusted host: 'host' (from line 1 of file.txt)"),
-        ]
-        assert actual == expected
+        expected = (
+            'INFO', "adding trusted host: 'host1' (from line 1 of file.txt)"
+        )
+        assert expected in actual
 
     def test_noop_always_unzip(self, finder):
         # noop, but confirm it can be set
diff --git a/tests/unit/test_utils.py b/tests/unit/test_utils.py
index ea252ceb2..51cf2a23a 100644
--- a/tests/unit/test_utils.py
+++ b/tests/unit/test_utils.py
@@ -38,6 +38,7 @@ from pip._internal.utils.glibc import (
 from pip._internal.utils.hashes import Hashes, MissingHashes
 from pip._internal.utils.misc import (
     HiddenText,
+    build_netloc,
     build_url_from_netloc,
     call_subprocess,
     egg_link_path,
@@ -49,9 +50,9 @@ from pip._internal.utils.misc import (
     hide_value,
     make_command,
     make_subprocess_output_error,
-    netloc_has_port,
     normalize_path,
     normalize_version_info,
+    parse_netloc,
     path_to_display,
     path_to_url,
     redact_netloc,
@@ -1232,29 +1233,49 @@ def test_path_to_url_win():
     assert path_to_url('file') == 'file:' + urllib_request.pathname2url(path)
 
 
-@pytest.mark.parametrize('netloc, expected_url, expected_has_port', [
+@pytest.mark.parametrize('host_port, expected_netloc', [
     # Test domain name.
-    ('example.com', 'https://example.com', False),
-    ('example.com:5000', 'https://example.com:5000', True),
+    (('example.com', None), 'example.com'),
+    (('example.com', 5000), 'example.com:5000'),
     # Test IPv4 address.
-    ('127.0.0.1', 'https://127.0.0.1', False),
-    ('127.0.0.1:5000', 'https://127.0.0.1:5000', True),
+    (('127.0.0.1', None), '127.0.0.1'),
+    (('127.0.0.1', 5000), '127.0.0.1:5000'),
     # Test bare IPv6 address.
-    ('2001:DB6::1', 'https://[2001:DB6::1]', False),
+    (('2001:db6::1', None), '2001:db6::1'),
     # Test IPv6 with port.
-    ('[2001:DB6::1]:5000', 'https://[2001:DB6::1]:5000', True),
+    (('2001:db6::1', 5000), '[2001:db6::1]:5000'),
+])
+def test_build_netloc(host_port, expected_netloc):
+    assert build_netloc(*host_port) == expected_netloc
+
+
+@pytest.mark.parametrize('netloc, expected_url, expected_host_port', [
+    # Test domain name.
+    ('example.com', 'https://example.com', ('example.com', None)),
+    ('example.com:5000', 'https://example.com:5000', ('example.com', 5000)),
+    # Test IPv4 address.
+    ('127.0.0.1', 'https://127.0.0.1', ('127.0.0.1', None)),
+    ('127.0.0.1:5000', 'https://127.0.0.1:5000', ('127.0.0.1', 5000)),
+    # Test bare IPv6 address.
+    ('2001:db6::1', 'https://[2001:db6::1]', ('2001:db6::1', None)),
+    # Test IPv6 with port.
+    (
+        '[2001:db6::1]:5000',
+        'https://[2001:db6::1]:5000',
+        ('2001:db6::1', 5000)
+    ),
     # Test netloc with auth.
     (
         'user:password@localhost:5000',
         'https://user:password@localhost:5000',
-        True
+        ('localhost', 5000)
     )
 ])
-def test_build_url_from_netloc_and_netloc_has_port(
-    netloc, expected_url, expected_has_port,
+def test_build_url_from_netloc_and_parse_netloc(
+    netloc, expected_url, expected_host_port,
 ):
     assert build_url_from_netloc(netloc) == expected_url
-    assert netloc_has_port(netloc) is expected_has_port
+    assert parse_netloc(netloc) == expected_host_port
 
 
 @pytest.mark.parametrize('netloc, expected', [