23 lines
1,006 B
Text
23 lines
1,006 B
Text
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MUSCLE is multiple alignment software for protein and nucleotide sequences.
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The name stands for multiple sequence comparison by log-expectation.
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A range of options is provided that give you the choice of optimizing
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accuracy, speed, or some compromise between the two. Default parameters are
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those that give the best average accuracy in the published tests. MUSCLE
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can achieve both better average accuracy and better speed than CLUSTALW or
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T-Coffee, depending on the chosen options.
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Citation:
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Edgar, R. C. (2004) MUSCLE: multiple sequence alignment with high accuracy
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and high throughput. Nucleic Acids Research 32(5): 1792-1797.
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Edgar, R. C. (2004) MUSCLE: a multiple sequence alignment method with
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reduced time and space complexity. BMC Bioinformatics 5(1): 113.
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The NAR paper gives only a brief overview of the algorithm and
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implementation details. For a full discussion of the method and many of
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the non-default options that it offers, please see the BMC paper.
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WWW: http://www.drive5.com/muscle/
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