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profiles, using the Smith-Waterman algorithm. PR: ports/67811 Submitted by: Fernan Aguero <fernan@iib.unsam.edu.ar>
18 lines
916 B
Text
18 lines
916 B
Text
ARIADNE is a package of two programs, ariadne and prospero, that compare
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protein sequences and profiles using the Smith-Waterman algorithm, and
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assesses statistical significance using a new accurate formula,
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described in Mott, 2000, "Accurate Formula for P-values of gapped local
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sequence and profile alignments" J. Mol Biol. 300:649-659.
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The sequence/profile comparison algorithms used in ARIADNE are standard,
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and are probably not the fastest implementations available. The novel
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part is the method for determining statistical significance, which will
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give thresholds of significance that are accurate to within 5% 95% of
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the time.
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The package is written in ANSI C. You are free to incorporate the method
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used for assessing statistical significance into third-party code,
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provided you cite the above reference. The routines for assessing
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significance are all in gaplib.c
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WWW: http://www.well.ox.ac.uk/ariadne/
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