Highlights
* New Media Manager
+ Beautiful interface: A streamlined, all-new experience
+ Create galleries faster with drag-and-drop reordering,
inline caption editing, and simplified controls
+ Insert multiple images at once with Shift/Ctrl+click
* New Default Theme - Twenty Twelve
+ Simple, flexible, elegant
+ Mobile-first, responsive design
+ Gorgeous Open Sans typeface
+ Uses the latest Theme Features
* Admin Enhancements
+ New Welcome Screen
+ Retina-Ready (HiDPI) Admin
+ Hide Link Manager for new installs
+ Better accessibility for screenreaders, touch devices, and
keyboard users
+ More polish on admin screens, including a new color picker
* For Developers
+ WP_Comment_Query and WP_User_Query accept now meta queries
just like WP_Query
+ Meta queries now support querying for objects without a
particular meta key
+ Post objects are now instances of a WP_Post class, which
improves performance and caching
+ Multisite's switch_to_blog() is now significantly faster and
more reliable
+ WordPress has added the Underscore and Backbone JavaScript
libraries
+ TinyMCE, jQuery, jQuery UI, and SimplePie have all been
updated to the latest versions
+ Image Editing API for cropping, scaling, etc., that uses
ImageMagick as well as GD
+ XML-RPC: Now always enabled and supports fetching users,
managing post revisions, searching
+ New "show_admin_column" parameter for register_taxonomy()
allows automatic creation of taxonomy columns on associated post-types.